The invention discloses a safe interlocking device for a power distribution cabinet, and the device comprises a power distribution cabinet front door, a power distribution cabinet rear door, and a power distribution cabinet top plate. The lower surface of the power distribution cabinet top plate is sequentially connected with a spring limiting block and a guide block in a fixed manner from the left to the right. The other ends of the spring limiting block and the guide block are respectively in fixed connection with a bottom plate. The guide block is provided with a through hole, and a limiting rod is inserted into the through hole. The central part of the limiting rod is provided with a projection, and the projection is disposed between the spring limiting block and the guide block. A spring is fixedly connected between the spring limiting block and the projection, and sleeves the outer side of the limiting rod. Two sides of the bottom plate are also fixedly connected with side baffleplates, and the side baffle plates are provided with openings a. A side surface of the power distribution cabinet rear door is provided with an opening b, and fixing devices are inserted into the openings a and b. The device is simple in structure, is reliable in operation, and is not liable to be damaged.