The invention discloses a preparation technology of rayon cationic polyester wrap yarn irregular-stripe cloth. The technology includes the following steps that firstly, 50% of rayon, 25% of cationic yarn and 25% of polyester fiber are subjected to crossed blending to form multi-fiber two-sided jersey, and the weaving tension is adjusted in the weaving process to make the polyester yarn only exposed to the surface of the two-sided jersey and interwoven with the cationic yarn; then, gray cloth is subjected to presetting before dyeing under 198 DEG C*26 y to guarantee that the cloth surface is flat without creases in the dyeing process, and the gray cloth is subjected to deoiling under 90 DEG C*20' with a 1% multifunctional emulgator to guarantee the dyeing uniformity; finally, the rayon andthe cationic yarn are subjected to one-bath dyeing (active and acidic), a kam cotton dyeing one-bath agent is added in dyeing, sufficient washing is carried out under 60 DEG C*60' and then under 98 DEG C*30' with 4.2% HAC added, then finishing is carried out, and the white-stripe polyester yarn emerges on the cloth surface to form an irregular-stripe cloth surface. The preparation technology of the rayon cationic polyester wrap yarn irregular-stripe cloth is environmentally friendly, saves energy and consumes little time.