The invention relates to a personnel air lock dynamic seal hand wheel penetrating part. The personnel air lock dynamic seal hand wheel penetrating part comprises a hand wheel shaft, a penetrating sleeve, a dynamic seal body and a seal end cover; the hand wheel shaft and the penetrating sleeve are relatively fixed in the axial direction and can relatively rotate, the dynamic seal body and the handwheel shaft are relatively fixed in the circumferential direction, two static seal rings are arranged between the dynamic seal body and the hand wheel shaft, two dynamic seal rings are arranged between the dynamic seal body and the seal end cover, an opening of a first leakage detection channel is arranged between the two static seal rings and the two dynamic seal rings, and an opening of a secondleakage detection channel is arranged between the two dynamic seal rings and the outer side of the seal end cover. The seal end cover is provided with a screw plug. The penetrating part has the beneficial effects that a spring compressing structure can better maintain the compressing force of the contact surface of the dynamic seal rings and the seal end cover, the influence of the surface wear of the dynamic seal rings to the seal can be reduced, due to the dual dynamic seal structures, during leakage detection, a dynamic seal still exists to exert the effect, and whole seal of the hand wheel penetrating part is maintained.