The invention relates to a comprehensive control method and device of a draught fan based on SF6 concentration and temperature. The device comprises a draught fan control loop connected with an SF6 gas concentration sensor and a temperature sensor which are configured in a GIS (geographic information system) room, the draught fan control loop comprises a remote/local handle, a local control button, a remote control button and a contactor; the remote/local handle is arranged at the input end of the draught fan control loop, one end of the remote/local handle is connected with the SF6 gas concentration sensor and the temperature sensor, and the other end is respectively connected with one end of the local control button and one end of the remote control button; the other end of the local control button and the other end of the remote control button are both connected with one end of the contactor, and the other end of the contactor serves as a load end and is connected with the SF6 gas concentration sensor and the temperature sensor. The method can be used for preventing the control scheme of mutual interference, and can be widely applied to the automatic control of draught fan equipment of an indoor GIS transformer substation.