基本信息:
- 专利标题： 一种模拟移动床色谱分离辅酶Q10和辅酶Q11的方法
- 专利标题（英）：Method for separating coenzyme Q10 from coenzyme Q11 through simulated moving bed chromatography
- 申请号：CN201711318687.3 申请日：2017-12-12
- 公开(公告)号：CN108084007A 公开(公告)日：2018-05-29
- 发明人： 鲍宗必 , 李敏 , 杨启炜 , 张治国 , 杨亦文 , 任其龙 , 邢华斌
- 申请人： 浙江大学
- 申请人地址： 浙江省杭州市西湖区余杭塘路866号
- 专利权人： 浙江大学
- 当前专利权人： 浙江大学
- 当前专利权人地址： 浙江省杭州市西湖区余杭塘路866号
- 代理机构： 杭州天勤知识产权代理有限公司
- 代理人： 胡红娟
- 主分类号： C07C46/10
- IPC分类号： C07C46/10 ; C07C50/28
The invention discloses a method for separating coenzyme Q10 from coenzyme Q11 through simulated moving bed chromatography. The method comprises the following steps: (1) dissolving a mixture of the coenzyme Q10 and the coenzyme Q11 in an organic solvent to prepare a feeding solution; (2) continuously introducing the feeding solution and eluent into a simulated moving bed chromatography system, continuously collecting an extraction solution rich in Q11 from an extraction hole of the simulated moving bed chromatography system, and continuously collecting raffinate liquid rich in Q10 from a raffinate hole; (3) performing post-treatment on the raffinate liquid to obtain a coenzyme Q10 monomer; performing post-treatment on the extraction solution to obtain a coenzyme Q11 monomer. The method disclosed by the invention has the advantages of simple preparation process, high degree of separation, large preparation amount, high recycling ratio, less solvent consumption and low production cost; moreover, the method is suitable for industrial production.
公开/授权文献:
- CN108084007B 一种模拟移动床色谱分离辅酶Q10和辅酶Q11的方法 公开/授权日：2020-05-08