The invention discloses tablets for preventing appendicitis and relates to the technical field of pharmaceuticals and health care products. The tablets comprise the following components in parts by weight: 40-60 parts of lonicera japonica, 40-60 parts of dandelion, 15-30 parts of cortex moutan, 10-20 parts of rheum officinale, 10-15 parts of red paeony roots, 8-12 parts of szechwan Chinaberry fruit, 8-12 parts of peach kernels, 8-12 parts of liquorice, 40-60 parts of a milk powder, 30-50 parts of dextrin, 30-50 parts of starch and 15-30 parts of a coating powder. The invention further discloses a preparation method of the tablets for preventing appendicitis. The raw and auxiliary materials have the effects of clearing heat and removing toxic materials, diminishing inflammation, activatingblood and dispersing blood stasis, tonifying deficiency and dispelling wind, and the tablets are capable of relieving pain and have obvious effects of preventing appendicitis. Moreover, due to the processes such as drying, decocting, filtering, concentrating, mixing, granulating, tabletting, coating and the like, the materials are effectively fused together, so that the maximum effects of the active ingredients are achieved, and an optimal effect is achieved.