基本信息:
- 专利标题： 一种阿法骨化醇的有关杂质PZB及其制备方法和用途
- 专利标题（英）：Impurity PZB related to alfacalcidol and preparing method and application thereof
- 申请号：CN201711488591.1 申请日：2017-12-30
- 公开(公告)号：CN108047108A 公开(公告)日：2018-05-18
- 发明人： 王芳 , 袁尚 , 郭彦飞 , 闵涛 , 胡永康 , 丁伯祥 , 王雪萌 , 葛元丽
- 申请人： 南京海融制药有限公司
- 申请人地址： 江苏省南京市高新开发区华康路122号
- 专利权人： 南京海融制药有限公司
- 当前专利权人： 南京海融制药有限公司
- 当前专利权人地址： 江苏省南京市高新开发区华康路122号
- 主分类号： C07C401/00
- IPC分类号： C07C401/00 ; G01N30/02
The invention discloses an impurity PZB related to alfacalcidol and a preparing method thereof, and belongs to the technical field of chemical pharmaceutical. The impurity PZB is (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2R,5R)-5-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol. The highly purified impurity PZB related to alfacalcidol can be applied as an impurity standard substance in alfacalcidol finished product detection and analysis, accordingly accurate locating and nature determine of an impurity in the alfacalcidol finished product detection and analysis are improved, the strengthened control over the impurity is facilitated, and thus the quality of an alfacalcidol finished product is improved. According tothe preparing method, raw materials are cheap and easy to obtain, the operation is simple, reproducibility is good, and the HPLC purity is larger than or equal to 99.5%.
公开/授权文献:
- CN108047108B 一种阿法骨化醇的有关杂质PZB及其制备方法和用途 公开/授权日：2019-09-20
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07C | 无环或碳环化合物 |
| ------C07C401/00 | 胆甾醇或它的衍生物的辐照产物；维生素D的衍生物，9,10断—环戊二烯并 |