
基本信息:
- 专利标题: 芥酸在制备预防或治疗甲型流感的药物中的应用
- 专利标题(英):Application of erucic acid in preparing medicine for preventing or treating vaccinum influenzae vivum
- 申请号:CN201810045581.9 申请日:2018-01-17
- 公开(公告)号:CN108014101A 公开(公告)日:2018-05-11
- 发明人: 杨子峰 , 李菁 , 梁晓丽 , 周倍贤 , 潘锡平 , 钟南山
- 申请人: 广州呼吸健康研究院 , 广州医科大学附属第一医院 , 呼吸疾病国家重点实验室
- 申请人地址: 广东省广州市沿江路151号; ;
- 专利权人: 广州呼吸健康研究院,广州医科大学附属第一医院,呼吸疾病国家重点实验室
- 当前专利权人: 广州呼吸健康研究院,广州医科大学附属第一医院,呼吸疾病国家重点实验室
- 当前专利权人地址: 广东省广州市沿江路151号; ;
- 代理机构: 广州新诺专利商标事务所有限公司
- 代理人: 曹爱红; 刘婉
- 主分类号: A61K31/201
- IPC分类号: A61K31/201 ; A61P31/16
The invention provides new application of erucic acid in preparing a medicine for preventing or treating vaccinum influenzae vivum. The invention also provides the medicine for preventing or treatingvaccinum influenzae vivum. The medicine is prepared from the active ingredient erucic acid. The inventor finds that the erucic acid has remarkable inhibitory activity on vaccinum influenzae vivum replicated and mediated inflammatory reaction. A liquid chip technology is adopted to prove that the erucic acid can remarkably inhibit the abnormal expression of an H1N1 virus infected A549 cell inflammatory factor and is in a dose-dependent relationship; an immunoblotting method is adopted to prove that the erucic acid can inhibit activation of a host inflammation-associated signal path and is in adose-dependent relationship; Annexin V-FITC/PI double-tagging flow cytometry is adopted to prove that the erucic acid can remarkably inhibit apoptotic lesion of a flue H1N1 induced host cell and is ina dose-dependent relationship. Animal experiments prove that the erucic acid can remarkably inhibit lung inflammation and apoptotic lesion induced by vaccinum influenzae vivum H1N1, and the survivaltime of rats is effectively prolonged.
公开/授权文献:
- CN108014101B 芥酸在制备预防或治疗甲型流感的药物中的应用 公开/授权日:2019-11-12
IPC结构图谱:
A | 人类生活必需 |
--A61 | 医学或兽医学;卫生学 |
----A61K | 医用、牙科用或梳妆用的配制品 |
------A61K31/00 | 含有机有效成分的医药配制品 |
--------A61K31/045 | .羟基化合物,例如醇类;其盐类,例如醇化物 |
----------A61K31/19 | ..羧酸;例如丙戊酸 |
------------A61K31/195 | ...含氨基的 |
--------------A61K31/201 | ....含1个或两个双键的,例如油酸或亚油酸 |