The invention relates to a vehicle steering knuckle clamping device. The device comprises a substrate. An upper end face of the substrate is fixedly connected with a steering knuckle front end limiting unit, a steering knuckle middle end limiting unit, and a steering knuckle rear end limiting unit. The lower end face of the substrate is fixedly connected with a base support. The base support comprises a base support substrate, a connecting plate fixed on the base support substrate, and supporting feet fixed on the lower end face of the base support substrate. The steering knuckle front end limiting unit is used to limit the front end of a steering knuckle. The steering knuckle middle end limiting unit comprises a second ]-shaped limiting block, a bearing fixed on the center of second ]-shaped limiting block, a first adjusting piece, and four limiting columns distributed on the upper end face of the substrate in a matrix. The first adjusting piece movably passes through the substrate. The front end of the first adjusting piece is fixedly connected with the center of the bearing. The vehicle steering knuckle clamping device is accurate in positioning and can adapt to vehicle steeringknuckles in various sizes, and flexibility is high.