基本信息:
- 专利标题： 含二氟乙基的亚硝胺类化合物及其制备方法
- 专利标题（英）：Difluoroethyl-containing nitrosamine compounds and preparation method thereof
- 申请号：CN201711111949.9 申请日：2017-11-13
- 公开(公告)号：CN107827774A 公开(公告)日：2018-03-23
- 发明人： 韩文勇 , 陈永正 , 汪建树 , 崔宝东 , 万南微
- 申请人： 遵义医学院
- 申请人地址： 贵州省遵义市大连路201号
- 专利权人： 遵义医学院
- 当前专利权人： 遵义医学院
- 当前专利权人地址： 贵州省遵义市大连路201号
- 代理机构： 遵义市遵科专利事务所
- 代理人： 刘创先
- 主分类号： C07C243/06
- IPC分类号： C07C243/06 ; C07C241/00 ; C07C255/65 ; C07C253/30 ; C07D307/52 ; C07D333/20
The invention discloses difluoroethyl-containing nitrosamine compounds and a preparation method thereof. A series of difluoroethyl-containing nitrosamine derivatives are obtained by taking carboxylicacid as a catalyst and carrying out an aza-Michael addition/nitrosation tandem reaction on three components, i.e., difluoroethylamine, tert-butyl nitrite and 1-aryl 2-nitroethylene at room temperaturein absence of other organic solvents. Molecular skeletons of the compounds contain potentially bioactive difluoroethyl and nitrosamine groups, thus establishing a material basis for drug discovery and druggability evaluation, and having an important application value. The preparation method provided by the invention adopts the easy-to-obtain raw materials, does not need an additional organic solvent, and has the advantages of mild reaction conditions, simple operation, high yield and good substrate universality.
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07C | 无环或碳环化合物 |
| ------C07C243/00 | 含有氮原子之间以单键相连的链的化合物，例如肼、三氮烷 |
| --------C07C243/04 | .N-亚硝基化合物 |
| ----------C07C243/06 | ..N-亚硝基胺 |