The invention discloses a safe, efficient, durable, hydrophilic and antibacterial polyester material and a preparation method thereof. The hydrophilic and antibacterial polyester material comprises the following raw material components in parts by mass: 10 to 90 parts of di-tert-butyl dicarbonate ester aspartic acid dimethyl ester monomer, 10 to 100 parts of diacid dibasic alcohol ester monomer, 0.1 to 5 parts of catalyst and 10 to 90 parts of levofloxacin. The preparation method comprises the following steps: putting the di-tert-butyl dicarbonate ester aspartic acid dimethyl ester monomer andthe diacid dibasic alcohol ester monomer into a container, performing reaction, heating and vacuumizing; putting the polymer into trichloromethane to dissolve, dropwise adding trifluoroacetic acid, pouring into methanol, and vacuum-drying the precipitated solid, putting tert-butyl oxycarbonyl 6-aminocaproic acid and the like into dimethyl sulfoxide and staying overnight; after adding the polymerand performing reaction, performing precipitation in the methanol to obtain the hydrophilic and antibacterial polyester material. The hydrophilic and antibacterial polyester material has efficient anddurable hydrophilic and antibacterial effects, and the polyester material generated by polymerization has high biocompatibility; the preparation method is mild in condition and low in energy consumption.