The invention discloses a curing material for fixing manganese in river bottom mud based on attapulgite. The curing material for fixing manganese in river bottom mud based on attapulgite is prepared according to the following steps: cleaning attapulgite and then modifying with a mixed solution of 4-3-fluorophenyl-3-thiosemicarbazide, 2-brooethyl-tetrahydropyrane, 3-phenyl isoquinoline and hexenylmethyl dichlorosilane, thereby acquiring a material A; modifying the material A with the mixed solution of NbCl4, AlCl3, Co(NO3)2 and Mg(NO3)2, thereby acquiring a material B; modifying the material B with the mixed solution of 1,3-diisopropyl-2-thiourea, trichlorine-2-carbon silane and methylsulfonylacetone, thereby acquiring a material C; modifying the material C with the mixed solution of allylthiourea, 3-phenylthiophene and imidazo [1,2-B] pyridazine-2-formic acid, thereby acquiring the end product, namely, the curing material for fixing manganese in river bottom mud based on attapulgite.