基本信息:
- 专利标题： 杜松烷型倍半萜类化合物及其制备方法和在制药中的用途
- 专利标题（英）：Cadinane sesquiterpene compounds, preparation method and use thereof in medicine preparation
- 申请号：CN201610386821.2 申请日：2016-06-05
- 公开(公告)号：CN107459446A 公开(公告)日：2017-12-12
- 发明人： 胡金锋 , 王立军 , 熊娟 , 唐宇 , 麻光磊
- 申请人： 复旦大学
- 申请人地址： 上海市杨浦区邯郸路220号
- 专利权人： 复旦大学
- 当前专利权人： 复旦大学
- 当前专利权人地址： 上海市杨浦区邯郸路220号
- 代理机构： 上海元一成知识产权代理事务所
- 代理人： 吴桂琴
- 主分类号： C07C49/733
- IPC分类号： C07C49/733 ; C07C45/78 ; A61P5/50 ; A61P3/10 ; A61P3/04
The invention belongs to the field of traditional Chinese medicine preparation, and specifically relates to cadinane sesquiterpene compounds extracted and separated from branches and leaves of Manglietia aromatic Dandy. The preparation method provided by the invention uses technologies of infrared, ultraviolet, mass spectrum (high and low resolution), 1D/2D nulcear magnetic resonance (NMR) and the like to confirm the structures of the cadinane sesquiterpene compounds, and uses a method of calculating circular dichroism (ECD) to confirm the absolute configurations of the cadinane sesquiterpene compounds. An in vitro inhibitory activity test is performed, and the result shows that the compounds have notable protein tyrosine phosphatase 1B(PTP1B) inhibitory activity, can be used as an inhibitor of the protein tyrosine phosphatase 1B and an insulin sensitizer, and can be further used for preparing medicines for preventing or curing the PTP1B mediated diseases, especially II-type diabetes, obesity and complications of the PTP1B mediated diseases, or lead compounds of the medicines.
公开/授权文献:
- CN107459446B 杜松烷型倍半萜类化合物及其制备方法和在制药中的用途 公开/授权日：2021-02-26
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07C | 无环或碳环化合物 |
| ------C07C49/00 | 酮；乙烯酮；二聚乙烯酮；酮的螯合物 |
| --------C07C49/04 | .有酮基连接在非环碳原子上的饱和化合物 |
| ----------C07C49/613 | ..多环的 |
| ------------C07C49/723 | ...多环的 |
| --------------C07C49/727 | ....酮基是稠环系的组成部分 |
| ----------------C07C49/733 | .....有两个环 |