The invention discloses an energy flow and information flow fusion method for a regional energy system oriented to a resident side and a highly-integrated regional energy system. The regional energy system is integrated with multiple home energy networks, an electricity supply and demand interactive service platform and a communication manager; each home energy network comprises a home intelligent energy gateway, distributed power supply equipment, energy storage equipment and a user load; the method comprises the steps as follows: the home intelligent energy gateway collects information of the user load, the power generation equipment and the energy storage equipment, and uploads the information to the electricity supply and demand interactive service platform through a communication pipeline; and the electricity supply and demand interactive service platform works out a home intelligent energy optimization coordination control strategy under a predetermined operating mode according to the information, a predetermined energy flow constraint condition and a predetermined optimization object, and issues the control strategy to the power generation equipment, the energy storage equipment and the user load through the communication manager and the home intelligent energy gateway, so as to perform energy flow control among the power generation equipment, the energy storage equipment and the user load according to the control strategy.