The present invention provides a relay protection setting value list generation method and device and belongs to the power system detection and management technical field. With the relay protection setting value list generation method and device provided by the embodiments of the invention adopted, the intelligent generation of a relay protection setting value list can be realized, errors caused by memory-based manual list filling can be avoided; useful help can be provided for operating mode personnel in daily mode arrangement; the protection setting value change condition of related devices can be prompted; whether current protection can cover the protection range of a line of a lower level and perform reclosing or realizes backup switching can be automatically prompted; work efficiency can be greatly improved; hidden dangers and risks caused by neglects can be prevented; effective technical support can be provided for dispatching and substation operation and maintenance personnel in accident handling; the intelligent dispatching level of dispatchers can be improved; and the safety and reliability of the operation of a power grid can be improved.