The invention discloses a multi-lumen balloon catheter comprising a first catheter body having a first balloon at the far end, a second catheter body penetrating into the first catheter body and having a second balloon at the far end, a guiding catheter penetrating into the second catheter body and being closed at the far end and of a hollow structure, and a handle sleeve device communicated with the first catheter body, the second catheter body and the guiding catheter, wherein the first balloon is provided with a plurality of micropores, the handle sleeve device at least comprises a first handle and a second handle, a perfusion chamber for delivering a therapeutic agent and communicating with a first handle cavity is formed between the first catheter body and the second catheter body, and a fluid communication chamber for delivering balloon dilation fluid and communicating with a second handle chamber is formed between the second catheter body and the guiding catheter. The multi-lumen balloon catheter of the invention can realize the effect of rapidly passing through complicated lesions and accurately positioning without relying on a guide wire, has the advantages of simple operation and good visibility, and solves the problem of effectively perfusing distal small vessels or branch CTO lesions for treatment.