基本信息:
- 专利标题： 一种2‑苯基‑1,2‑二氢萘‑1‑醇外消旋化合物及其衍生物的合成方法
- 专利标题（英）：Synthetic method of 2-phenyl-1,2-dihydronaphthalene-1-ol racemization compound and derivatives thereof
- 申请号：CN201710391062.3 申请日：2017-05-27
- 公开(公告)号：CN107235843A 公开(公告)日：2017-10-10
- 发明人： 杨定乔 , 仵瑞华 , 陈文坤 , 杨文
- 申请人： 华南师范大学
- 申请人地址： 广东省广州市大学城外环西路华南师范大学化学与环境学院
- 专利权人： 华南师范大学
- 当前专利权人： 华南师范大学
- 当前专利权人地址： 广东省广州市大学城外环西路华南师范大学化学与环境学院
- 代理机构： 深圳市精英专利事务所
- 代理人： 王文伶
- 主分类号： C07C201/12
- IPC分类号： C07C201/12 ; C07C205/18 ; C07C37/055 ; C07C39/38 ; C07C41/26 ; C07C41/22 ; C07C43/225 ; C07C43/23 ; C07C43/20 ; C07C29/10 ; C07C35/31 ; C07C35/52 ; C07C35/46 ; C07C41/18
The invention relates to the technical field of synthesis of dihydronaphthalene structure unit intermediates and in particular relates to a synthetic method of 2-phenyl-1,2-dihydronaphthalene-1-ol racemization compound and derivatives thereof as well as novel 2-phenyl-1,2-dihydronaphthalene-1-ol racemization compounds and derivatives thereof synthesized by the method. The synthetic method disclosed by the invention comprises the following steps: taking a transition metal compound formed by Pt(COD)Cl2 and an organic ligand as a catalyst, catalyzing oxabenzonorbornadiene to react with sodium arylsulfinate, and efficiently synthesizing the 2-phenyl-1,2-dihydronaphthalene-1-ol racemization compound and derivatives thereof. The reaction conditions are mild, and the reaction can be completed at the temperature of 50-80 DEG C. When the transition metal compound catalyst is formed by a proper amount of PPh3 serving as the organic ligand and Pt(COD)Cl2, an additive AgSbF6 is used and CH3OH serves as a solvent, the reaction time is short, and the yield of the synthesized 2-phenyl-1,2-dihydronaphthalene-1-ol racemization compound can reach 92%.
公开/授权文献:
- CN107235843B 一种2-苯基-1,2-二氢萘-1-醇外消旋化合物及其衍生物的合成方法 公开/授权日：2019-08-13
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07C | 无环或碳环化合物 |
| ------C07C201/00 | 硝酸酯或亚硝酸酯的制备，或硝基或亚硝基直接连在碳架上的化合物的制备 |
| --------C07C201/06 | .硝基化合物的制备 |
| ----------C07C201/12 | ..用不包括形成硝基的反应 |