The invention provides an efficient self-disinsection weather-resistance street lamp which comprises a lamp frame, a lamp post, a lamp holder and a base, wherein the lamp post, the lamp holder and the base are sequentially arranged from top to bottom. The lamp frame is fixed to the upper portion of the lamp post; a lamp cap is fixed to the lamp frame; a horizontally-arranged power grid is arranged in the lamp frame; the power grid divides the lamp frame into a bottom-tilted mosquito-insect collecting layer and an insecticidal layer from bottom to top; an ultraviolet lamp is arranged in the insecticidal layer; a telescopic motor is arranged at the top of the power grid; a cleaning brush is arranged at the end of the telescopic motor; a first partition plate, an air layer, a second partition plate and a bulb are arranged in the lamp cap from bottom to top; a water receiving opening is formed in the top of the lamp holder, and a pipeline is arranged inside the lamp holder; the bottommost end of the mosquito-insect collecting layer is connected with the pipeline; and the water receiving opening is connected with the pipeline. The efficient self-disinsection weather-resistance street lamp is simple in structure, low in cost and good in lighting effect, the life of the bulb is long, the insecticidal, disinsection and self-cleaning effects can further be achieved, and meanwhile killed insects can further be used as fertilizers of plants near the street lamp.