The invention provides industrial atmospheric corrosion resistant and high strength bolt steel for a non-spraying bridge structure and a manufacturing method of the industrial atmospheric corrosion resistant and high strength bolt steel, and belongs to the technical field of high strength bolt steel for the bridge structure. The industrial atmospheric corrosion resistant and high strength bolt steel for the non-spraying bridge structure comprises, by weight, 0.16-0.45% of C, 0.01-2.2% of Si, 0.3-2.2% of Mn, 0.001-0.024% of P, 0.002-0.025% of S, 0.0005-0.0100% of B, 0.04-0.50% of Ti, 0.01-0.20% of V, 0.001-0.10% of Al, 0.001-0.34% of Cr, 0.2-0.5% of Cu, 0.2-1.5% of Ni and the balance Fe and trace of impurities. According to the high strength and weather resistant bolt steel, the corrosion resistance index I worked out according to the chemical composition prediction formula is larger than or equal to 6.3, the bolt steel is suitable for producing bolts with the specification range M of 16-30 mm, after the bolt steel is made into bolts in a bolt machining plant, the quenching-and-tempering heat treatment process system is combination of oil quenching of 840-920 DEG C and tempering of 380-625 DEG C, and the optimal strength and toughness match is obtained. The industrial atmospheric corrosion resistant and high strength bolt steel for the non-spraying bridge structure and the manufacturing method of the industrial atmospheric corrosion resistant and high strength bolt steel have the advantages that the bolt steel is applicable to matched connection of plates and profiles of the non-spraying bridge structure and has excellent industrial atmospheric corrosion resistance and low temperature resistance.