The invention provides a method and device for pressurized sealing of sand hole leakage. The device comprises an outer shell (1), an inner shell (2), a movable connecting body (3), a vacuum valve (4) and a sealing piece (6). The inner shell (2) comprises a pipe body part and a flange part located at one end of the pipe body part. The end, away from the flange part, of a pipe hole of the pipe body part is larger than a to-be-sealed sand hole. The inner shell (2) is surrounded by the cylindrical outer shell (1), one end of the cylindrical outer shell (1) is connected with the periphery of the flange part in a sealing mode through the movable connecting body (3), and the other end of the cylindrical outer shell (1) is flush with the end, away from the flange part, of the pipe body part. The vacuum valve (4) is located on the outer shell (1) or located on the flange part of the inner shell (2). The sealing piece (6) is used for being connected with the end, close to the flange part, of the pipe hole of the pipe body part in a sealing mode. Through use of the device provided by the invention, the influence of media in a pressure container on leak stoppage work can be effectively reduced, the construction time is short, the effect is good, and the success rate is high.