基本信息:
- 专利标题： 一种硫辛酸修饰的固有无序蛋白纳米载体及其制备方法和应用
- 专利标题（英）：Lipoic acid modified intrinsically disordered protein nano-carrier, preparation method thereof and application of nano-carrier
- 申请号：CN201710202680.9 申请日：2017-03-30
- 公开(公告)号：CN107129522A 公开(公告)日：2017-09-05
- 发明人： 管斐 , 宫春爱 , 高原 , 武鑫
- 申请人： 上海维洱生物医药科技有限公司
- 申请人地址： 上海市青浦区华浦路500号6幢A区1层158室
- 专利权人： 上海维洱生物医药科技有限公司
- 当前专利权人： 上海维洱生物医药科技有限公司,上海宝龙药业股份有限公司上海宝龙安庆药业有限公司宝龙药业有限公司
- 当前专利权人地址： 上海市青浦区华浦路500号6幢A区1层158室
- 代理机构： 上海顺华专利代理有限责任公司
- 代理人： 陆林辉
- 主分类号： C07K7/08
- IPC分类号： C07K7/08 ; C07K1/02 ; A61K9/107 ; A61K48/00 ; A61K47/42 ; A61K31/7088 ; A61K31/337 ; A61P35/00
The invention relates to the technical field of medicines, in particular to a lipoic acid modified intrinsically disordered protein nano-carrier, a preparation method thereof and an application of the nano-carrier. The nano-carrier is crosslinked by disulfide bonds of lipoic acid, formed polypeptide polymer can be rapidly degraded in cells and cannot be accumulated in the cells, and amino acid forming a polypeptide carrier exists in vivo and has no toxic and side effects on the cells and a human body. CCK-8 cell proliferation assay indicates that the prepared nano-carrier has low cell toxicity and good gene and chemotherapeutic drug co-carrier capacity, can successfully deliver sensitivity of autophagic specificity enhanced cancer cells to chemotherapeutic drugs caused by siRNA suppressive chemotherapeutic drugs in breast cancer therapy, promotes breast cancer cell apoptosis and accordingly becomes a targeted, efficient and low-toxicity nano-scale delivery system in breast cancer therapy.
公开/授权文献:
- CN107129522B 一种硫辛酸修饰的固有无序蛋白纳米载体及其制备方法和应用 公开/授权日：2020-08-07
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07K | 肽 |
| ------C07K7/00 | 在完全确定的序列中含有5~20个氨基酸的肽；其衍生物 |
| --------C07K7/04 | .仅含有正常肽键的直链肽 |
| ----------C07K7/08 | ..含有12~20个氨基酸 |