The invention discloses a frame and wall board structure system which comprises frame columns, frame beams and prefabricated wall panels. The frame columns are hinged to the frame beams, the prefabricated wall panels have the capacity of bearing vertical load and resisting lateral load, the prefabricated wall panels are spliced and form at least one tubular structure in an enclosing mode, and the frame columns and/or the frame beams and the prefabricated wall panels form reliable connection. According to the technical scheme, a pure dry method connecting mode is adopted, the frame beams and the frame columns are subjected to dry hinging, the prefabricated wall panels are in dry connection with frames, construction can be conducted continuously, the construction speed is greatly increased, the construction period is shortened, the prefabricated wall panels capable of bearing the vertical load and resisting the lateral load are introduced into the frame structure, the frame and wall board structure system is formed, the frame structure is subjected to transmission force between the frame beams and the prefabricated wall panels, due to the fact that the horizontal lateral stiffness of the prefabricated wall panels is high, the horizontal seismic force is borne by the prefabricated wall panels, the frame structure only bears the vertical load, and the stability of the whole building can meet the requirement.