The invention discloses a centralized management and control system for a computer room. The system comprises the computer room and a monitoring room, wherein network equipment is arranged in the computer room; a master control computer is arranged in the monitoring room; a console port is arranged on each piece of the network equipment, and is connected to an input end of a console port concentrator in the monitoring room through a special configuration line; output ends are further arranged on the console port concentrator; a safety cover is arranged on each output end; more than two connection lines are arranged on the master control computer and used for being connected with the output ends of the console port concentrator; safety doors are arranged in the monitoring room and the computer room; a fingerprint unlocking device is arranged on each safety door; a plurality of monitoring cameras are arranged in the monitoring room and the computer room, so as to avoid monitoring dead angles; and whenever a user manages the network equipment through the master control computer, a system of the master control computer can carry out full-process operation recording. The system provided by the invention has the advantages that fully enclosed management and monitoring of the computer room are achieved, so that a large amount of time can be saved during debugging or troubleshooting of the network equipment, and the working efficiency and the computer room safety can be improved.