基本信息:
- 专利标题： 2‑甲氧基‑5‑香叶基对苯醌衍生物和Scabellone C的制备方法
- 专利标题（英）：Preparation methods of 2-methoxyl-5-geranyl-p-benzoquinone derivative and Scabellone C
- 申请号：CN201710447420.8 申请日：2017-06-14
- 公开(公告)号：CN107043386A 公开(公告)日：2017-08-15
- 发明人： 胡向东 , 于涛
- 申请人： 西北大学
- 申请人地址： 陕西省西安市长安区学府大道1号
- 专利权人： 西北大学
- 当前专利权人： 西北大学
- 当前专利权人地址： 陕西省西安市长安区学府大道1号
- 代理机构： 深圳市合道英联专利事务所
- 代理人： 廉红果
- 主分类号： C07D493/04
- IPC分类号： C07D493/04 ; C07C46/02 ; C07C50/30
The invention discloses a preparation method of a 2-methoxyl-5-geranyl p-benzoquinone derivative. The method is implemented by the following steps: 1, preparing a middle product 1,2,4-trimethoxy-3-trimethylsilyl-benzene; 2, preparing a middle product 1,2,4-trimethoxy-6-geranyl-benzene; 3, preparing a target. The invention further discloses a preparation method of Scabellone C. According to the preparation methods, 1,2,4-trimethoxy benzene is used as a raw material, so that the 2-methoxyl-5-geranyl-p-benzoquinone derivative (a coupled product) can be successfully obtained by one step through ammonium ceric nitrate oxidization under a common organic solvent condition, and the Scabellone C is synthesized under a condition of selecting different organic solvents; therefore, a breakthrough for zero yield in the aspect of preparation of the Scabellone C in the prior art is realized; meanwhile, by the adoption of the preparation method disclosed by the invention, the yield of the Scabellone C is extremely high.
公开/授权文献:
- CN107043386B 2-甲氧基-6-香叶基对苯醌衍生物和Scabellone C的制备方法 公开/授权日：2019-04-16
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D493/00 | 杂环化合物，在稠环系中含有氧原子作为仅有的杂环原子 |
| --------C07D493/02 | .在稠环系中含有两个杂环 |
| ----------C07D493/04 | ..邻位稠合系 |