The invention relates to a compounding method of a medical intermediate carbonyl-substituted aryl thioether compound. The method includes that a formula-(1) compound reacts with a formula-(II) compound in organic solvent with the presence of catalysts, organic ligands, activators and alkali at the nitrogen atmosphere, and a formula-(III) compound is obtained through post-treatment after reaction, wherein each R1 is C1-C6 alkyl independently, R2 is C1-C6 alkyl, C1-C6 alkoxy, halogen or nitryl, and X is halogen. The compounding method of the carbonyl-substituted aryl thioether compound has the advantages that a novel composite reaction system is adopted, and the target product can be obtained at high yield through comprehensive selection of the catalysts, the organic ligands, the activators, the alkali and the organic solvent; the reaction process is moderate, needs of the fields such as chemical engineering and medicine are met, and market prospect is wide.