基本信息:
- 专利标题： 抗人补体D因子的单克隆抗体及其用途
- 申请号：CN201710229191.2 申请日：2017-04-10
- 公开(公告)号：CN106905431B 公开(公告)日：2020-01-17
- 发明人： 高永娟 , 孙乃超 , 周若芸 , 李强 , 刘瑞贤 , 金宜慧
- 申请人： 旭华(上海)生物研发中心有限公司
- 申请人地址： 上海市浦东新区碧波路518号315室
- 专利权人： 旭华(上海)生物研发中心有限公司
- 当前专利权人： 旭华(上海)生物研发中心有限公司
- 当前专利权人地址： 上海市浦东新区碧波路518号315室
- 代理机构： 上海巅石知识产权代理事务所
- 代理人： 张琤; 蒋舫玮
- 主分类号： C07K16/40
- IPC分类号： C07K16/40 ; C12N15/13 ; C12P21/02 ; A61K39/395 ; A61P27/02 ; A61P37/02 ; A61P19/02 ; A61P29/00 ; A61P11/00 ; A61P13/12 ; A61P19/04
The present invention provides an antibody and an antigen binding fragment of the antibody, the antibody is specifically bonded with human D factor in high affinity, the present invention also provides a nucleic acid molecule for encoding the antibody and the antigen binding fragment, an expression vector for expression of the antibody and the antigen binding fragment, host cells, and a production method of the antibody and the antigen binding fragment. In addition, the invention also provides an immune conjugates and a pharmaceutical composition comprising the antibody and the antigen binding fragment and use of the antibody and the antigen binding fragment in preparation of drugs for treatment of various diseases (including age-related macular degeneration (AMD), autoimmune disease, systemic lupus erythematosus, glomerulonephritis, rheumatoid arthritis and adult respiratory distress).
公开/授权文献:
- CN106905431A 抗人补体D因子的单克隆抗体及其用途 公开/授权日：2017-06-30