基本信息:
- 专利标题： 一种普拉克索杂质B的合成方法
- 专利标题（英）：Synthetic method of pramipexole impurity B
- 申请号：CN201710006833.2 申请日：2017-01-05
- 公开(公告)号：CN106905258A 公开(公告)日：2017-06-30
- 发明人： 杨继斌 , 程宜兴 , 朱金龙 , 张超 , 王奇超 , 张熠能
- 申请人： 上海昕盛医药科技有限公司 , 浙江宏冠生物药业有限公司
- 申请人地址： 上海市浦东新区中科路699号C栋4楼;
- 专利权人： 上海昕盛医药科技有限公司,浙江宏冠生物药业有限公司
- 当前专利权人： 宏冠生物药业有限公司
- 当前专利权人地址： 上海市浦东新区中科路699号C栋4楼;
- 代理机构： 杭州斯可睿专利事务所有限公司
- 代理人： 钦荣燕
- 优先权： 2016111866914 20161220 CN
- 主分类号： C07D277/60
- IPC分类号： C07D277/60
The invention belongs to the technical field of medicine production and in particular to a preparation method of a pramipexole impurity. The synthetic method of the pramipexole impurity B comprises the following steps of: S1, adding (S)-2,6-diamino-4,5,6,7-tetrahydrobenzothiazole, alkali, propionic anhydride and DMAP into an organic solvent to synthesize (S)-N,N'-(4,5,6,7-tetrahydrobenzothiazole-2,6-diyl)dipropanamide; and S2, adding the (S)-N,N'-(4,5,6,7-tetrahydrobenzothiazole-2,6-diyl)dipropanamide obtained by the reaction in the S1 into an organic solvent and reducing system, wherein the reaction product is the pramipexole impurity B. The synthetic method of the pramipexole impurity B is simple in process route and convenient to operate, and the synthesized pramipexole impurity B can be used as a reference substance for detecting related substances of pramipexole, and the method is applied to quality control of pramipexole and related preparations.
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D277/00 | 杂环化合物，含有1,3-噻唑或氢化1,3-噻唑环 |
| --------C07D277/60 | .和碳环或环系稠合 |