![一种4‑乙酰氨基苯磺酰氯的环保制备方法](/CN/2017/1/38/images/201710190640.jpg)
基本信息:
- 专利标题: 一种4‑乙酰氨基苯磺酰氯的环保制备方法
- 专利标题(英):Environment-friendly preparation method for 4-(acetylamino)benzenesulfonyl chloride
- 申请号:CN201710190640.7 申请日:2017-03-28
- 公开(公告)号:CN106866468A 公开(公告)日:2017-06-20
- 发明人: 计建明 , 钱炜雯 , 朱凤林
- 申请人: 吴赣药业(苏州)有限公司
- 申请人地址: 江苏省苏州市吴江区同里镇屯村东关路159号
- 专利权人: 吴赣药业(苏州)有限公司
- 当前专利权人: 吴赣药业(苏州)有限公司
- 当前专利权人地址: 江苏省苏州市吴江区同里镇屯村东关路159号
- 代理机构: 苏州创元专利商标事务所有限公司
- 代理人: 仇波
- 主分类号: C07C303/08
- IPC分类号: C07C303/08 ; C07C303/44 ; C07C309/88
The invention relates to an environment-friendly preparation method for 4-(acetylamino)benzenesulfonyl chloride. The method comprises the following steps: (a) carrying out a chlorosulfonation reaction on excessive chlorosulfonic acid and N-phenylacetamide in a first vessel, so as to prepare a first mixture; (b) adding the first mixture into a second vessel containing water, controlling the internal temperature of the second vessel to 15 DEG C to 20 DEG C, and carrying out mixing, so as to obtain a second mixture, wherein the mass ratio of the water to N-phenylacetamide is (1 to 5): 6; and (c) adding the second mixture into a third vessel containing water, controlling the temperature of the third vessel to 2 DEG C to 10 DEG C so as to separate out 4-(acetylamino)benzenesulfonyl chloride, carrying out filtering, and then, carrying out washing repeatedly, thereby obtaining the 4-(acetylamino)benzenesulfonyl chloride, wherein the mass ratio of the water to N-phenylacetamide is (5 to 15): 1. According to the method, the discharging of wastewater can be reduced, the quality is stable, no off odor is generated, and the yield can be increased.
公开/授权文献:
- CN106866468B 一种4-乙酰氨基苯磺酰氯的环保制备方法 公开/授权日:2019-01-18
IPC结构图谱:
C | 化学;冶金 |
--C07 | 有机化学 |
----C07C | 无环或碳环化合物 |
------C07C303/00 | 硫酸酯或硫酸酰胺的制备;磺酸或其酯、卤化物、酐或酰胺的制备 |
--------C07C303/02 | .磺酸或其卤化物的 |
----------C07C303/04 | ..用磺基或卤磺酰基取代氢原子 |
------------C07C303/08 | ...与卤代磺酸反应 |