
基本信息:
- 专利标题: 脯氨酸羟化酶及其应用
- 专利标题(英):Prolyl hydroxylase and application thereof
- 申请号:CN201610971207.2 申请日:2016-11-04
- 公开(公告)号:CN106834244A 公开(公告)日:2017-06-13
- 发明人: 洪浩 , 詹姆斯·盖吉 , 卢江平 , 张娜 , 于文燕 , 刘芳 , 李艳君 , 黄鑫 , 高娟 , 张克俭 , 马玉磊 , 魏俊璐
- 申请人: 凯莱英医药集团(天津)股份有限公司 , 凯莱英生命科学技术(天津)有限公司 , 天津凯莱英制药有限公司 , 凯莱英医药化学(阜新)技术有限公司 , 吉林凯莱英医药化学有限公司
- 申请人地址: 天津市滨海新区经济技术开发区洞庭三街6号; ; ; ;
- 专利权人: 凯莱英医药集团(天津)股份有限公司,凯莱英生命科学技术(天津)有限公司,天津凯莱英制药有限公司,凯莱英医药化学(阜新)技术有限公司,吉林凯莱英医药化学有限公司
- 当前专利权人: 凯莱英医药集团(天津)股份有限公司,凯莱英生命科学技术(天津)有限公司,天津凯莱英制药有限公司,凯莱英医药化学(阜新)技术有限公司,吉林凯莱英医药化学有限公司
- 当前专利权人地址: 天津市滨海新区经济技术开发区洞庭三街6号; ; ; ;
- 代理机构: 北京康信知识产权代理有限责任公司
- 代理人: 赵囡囡; 吴贵明
- 主分类号: C12N9/02
- IPC分类号: C12N9/02 ; C12N15/53 ; C12P13/24
The invention provides prolyl hydroxylase and application thereof. The prolyl hydroxylase comprises (a) a protein with an amino acid sequence as shown by SEQ ID NO: 2; (b) a protein with the amino acid sequence as shown by the SEQ ID NO: 2 being mutated through one or more amino acids, and prolyl hydroxylase activity; or (c) a protein with mutation of one or more amino acids in the (b), prolyl hydroxylase activity, and at least 78 percent of homology with the amino acid sequence of the protein in the (b). Due to the protein with the amino acid sequence as shown by the SEQ ID NO: 2 and a mutant obtained through improving the protein by utilizing a gene engineering means, the prolyl hydroxylase provided by the invention has higher catalysis specifity compared with existing prolyl hydroxylase, or the catalytic activity is remarkably improved.
公开/授权文献:
- CN106834244B 脯氨酸羟化酶及其应用 公开/授权日:2021-07-06