![一种能进行MR‑荧光双模态成像的可降解纳米胶束及其制备方法和应用](/CN/2017/1/19/images/201710099640.jpg)
基本信息:
- 专利标题: 一种能进行MR‑荧光双模态成像的可降解纳米胶束及其制备方法和应用
- 专利标题(英):Degradable nano-micelle capable of performing MR-fluorescence bimodal imaging as well as preparation method and application of degradable nano-micelle
- 申请号:CN201710099640.6 申请日:2017-02-23
- 公开(公告)号:CN106822924A 公开(公告)日:2017-06-13
- 发明人: 沈君 , 卢烈静 , 帅心涛 , 王勇
- 申请人: 中山大学
- 申请人地址: 广东省广州市海珠区新港西路135号
- 专利权人: 中山大学
- 当前专利权人: 中山大学
- 当前专利权人地址: 广东省广州市海珠区新港西路135号
- 代理机构: 广州粤高专利商标代理有限公司
- 代理人: 单香杰
- 主分类号: A61K49/00
- IPC分类号: A61K49/00 ; A61K49/12 ; A61K49/18 ; C08G69/48
The invention belongs to the field of nano medicine and biomedical engineering and particularly discloses degradable nano-micelle capable of performing MR (magnetic resonance)-fluorescence bimodal imaging as well as a preparation method and an application of the degradable nano-micelle. The nano-micelle is based on amphipathic block polymer support PAsp(DMA)-CA2. A hydrophobic core of the micelle is used for supporting hydrophobic SPIO (superparamagnetic iron oxide) and fluorescent dye Nile red, neutral stem cells can be labeled in vitro safely and efficiently, after in-vivo transplantation of the neutral stem cells, distribution and migration conditions of the neutral stem cells in vivo can be traced in real time, safe and efficient MR-fluorescence bimodal imaging tracing of the stem cells can be realized, and the nano-micelle has broad application prospects.
公开/授权文献:
- CN106822924B 一种能进行MR-荧光双模态成像的可降解纳米胶束及其制备方法和应用 公开/授权日:2020-06-16
IPC结构图谱:
A | 人类生活必需 |
--A61 | 医学或兽医学;卫生学 |
----A61K | 医用、牙科用或梳妆用的配制品 |
------A61K49/00 | 体内试验用的配制品 |