The invention provides a transformer station secondary cable laying and cleaning protective device including a mount, a clamping cleaner, and a combination connecting piece, the mount includes a body, a connecting piece, a connecting bolt, a clamping screw rod, and a clamping block, the connecting piece is connected with the body through the connecting bolt, the clamping screw rod is arranged on the connecting piece, the clamping block is connected with one end of the clamping bolt, the clamping cleaner includes a frame, a first screw rod, a second screw rod, a first extension spring, a second extension spring, a first roller brush, and a second roller brush, the first roller brush and the second roller brush are arranged on the frame through the first screw rod and the second screw rod respectively, and the first extension spring and the second extension spring connect the first screw rod and the second screw rod. When the protective device is used, the clamping cleaner is fixedly connected with the mount through the combination connecting piece. The protective device provided is simple in structure, low in cost, and convenient to carry and install; and moreover, when the protective device is used, the protective device can effectively protect civil engineering and electric equipment of a new building transformer station; and meanwhile, the protective device can further protect and clean a secondary cable itself.