基本信息:
- 专利标题： 芳基取代联苯、吡咯、吲哚或联萘型单膦配体制备方法
- 申请号：CN201611201244.1 申请日：2016-12-22
- 公开(公告)号：CN106674279B 公开(公告)日：2018-06-05
- 发明人： 邱晓东 , 王敏燕 , 赵越 , 浦兴晖 , 胡杰峰 , 史壮志
- 申请人： 南京大学
- 申请人地址： 江苏省南京市栖霞区仙林大道163号
- 专利权人： 南京大学
- 当前专利权人： 南京大学
- 当前专利权人地址： 江苏省南京市栖霞区仙林大道163号
- 代理机构： 江苏致邦律师事务所
- 代理人： 徐蓓
- 主分类号： C07F9/50
- IPC分类号： C07F9/50 ; C07F9/572 ; C07F9/655 ; C07F9/6553 ; C07F9/58 ; C07F9/60
The invention discloses a preparation method for a new-style monophosphine ligand. The method comprises the following process: (a) by taking a commercialized biphenyl, pyrrole, indol or binaphthyl monophosphine ligand as a raw material, under the protection of inert gas, controlling the reaction temperature to be 70-150 DEG C in an organic solution under the participation of an inorganic base, and carrying out monovalent rhodium catalysis on the raw material and an aromatic halogenated compound to prepare the new-style aryl-substituted biphenyl, pyrrole, indol or binaphthyl monophosphine ligand. The synthetic route is not reported in literature, and the raw material is cheap and easily available; and the unit operation is simple, and the requirement on equipment is low, so that the preparation method is suitable for quickly constructing a new-style monophosphine ligand library.
公开/授权文献:
- CN106674279A 芳基取代联苯、吡咯、吲哚或联萘型单膦配体制备方法 公开/授权日：2017-05-17