
基本信息:
- 专利标题: 一种罗博卢酮的生物合成基因簇及其应用
- 专利标题(英):Biosynthetic gene cluster of Rubrolone and application of biosynthetic gene cluster
- 申请号:CN201610051232.9 申请日:2016-01-26
- 公开(公告)号:CN106636141A 公开(公告)日:2017-05-10
- 发明人: 黄胜雄 , 纪旭 , 颜一军 , 杨静 , 罗剑英
- 申请人: 中国科学院昆明植物研究所
- 申请人地址: 云南省昆明市蓝黑路132号
- 专利权人: 中国科学院昆明植物研究所
- 当前专利权人: 中国科学院昆明植物研究所
- 当前专利权人地址: 云南省昆明市蓝黑路132号
- 代理机构: 昆明协立知识产权代理事务所
- 代理人: 谢嘉
- 主分类号: C12N15/53
- IPC分类号: C12N15/53 ; C12N15/55 ; C12N15/54 ; C12N15/31 ; C12N15/61 ; C12N15/60 ; C12N1/20 ; C12N15/76 ; C07D491/153 ; C07D221/16 ; C07D311/94 ; A61K31/436 ; A61K31/435 ; A61K31/352 ; A61P9/00 ; A61P39/06 ; C12R1/465
The invention provides a biosynthetic gene cluster of Rubrolone as a tropolone natural product, Streptomyces sp. CGMCC No.11535, a preparation method for preparing Rubrolone compounds 1-4 from the biosynthetic gene cluster and the Streptomyces sp., a medicinal composition taking the Rubrolone compounds as active components, and application of the biosynthetic gene cluster to pharmacy. By adopting all gene and protein information which is relevant to Rubrolone biosynthesis, a biosynthesis mechanism of the Rubrolone as the natural product is known, and materials and knowledge are provided for further genetic modification. Genes provided by the invention and a protein thereof can be used for finding compounds, genes or proteins applicable to medicine, industry or agriculture.
公开/授权文献:
- CN106636141B 一种罗博卢酮的生物合成基因簇及其应用 公开/授权日:2019-08-13