![二烷基氢化诺卜基苄基季铵盐的合成方法及其抗菌应用](/CN/2016/1/230/images/201611153439.jpg)
基本信息:
- 专利标题: 二烷基氢化诺卜基苄基季铵盐的合成方法及其抗菌应用
- 专利标题(英):Synthesis method of dialkyl hydrogenated nopyl benzyl quaternary ammonium salt, and antibacterial application thereof
- 申请号:CN201611153439.3 申请日:2016-12-14
- 公开(公告)号:CN106631818A 公开(公告)日:2017-05-10
- 发明人: 范国荣 , 金霖霖 , 肖转泉 , 陈金珠 , 王鹏 , 陈尚钘 , 王宗德 , 廖圣良 , 司红燕
- 申请人: 江西农业大学
- 申请人地址: 江西省南昌市经济技术开发区志敏大道1101号
- 专利权人: 江西农业大学
- 当前专利权人: 江西农业大学
- 当前专利权人地址: 江西省南昌市经济技术开发区志敏大道1101号
- 代理机构: 北京华仲龙腾专利代理事务所
- 代理人: 李静
- 主分类号: C07C209/12
- IPC分类号: C07C209/12 ; C07C211/63 ; A01N33/12 ; A01P3/00
The invention discloses a method for synthesizing a dialkyl hydrogenated nopyl benzyl quaternary ammonium salt compound, and antibacterial application of the compound. Dialkyl hydrogenated nopyl amine and a benzyl halide are directly subjected to one-step synthesis to obtain dialkyl hydrogenated nopyl benzyl quaternary ammonium salt; in an organic solvent, the dialkyl hydrogenated nopyl amine and the benzyl halide (chlorine, bromine and iodine) are fed into a conical flask according to a material ratio, wherein the conical flask is provided with a stirrer and a condensate backflow device; heating is performed for reaction; the reaction temperature is controlled to be 100 to 150 DEG C; the reaction time is controlled to be 1 to 3d. After reaction, products are subjected to suction filtration, washing, recrystallization and vacuum drying; seven dialkyl hydrogenated nopyl benzyl quaternary ammonium salt compounds are obtained through synthesis; the seven dialkyl hydrogenated nopyl benzyl quaternary ammonium salt compounds have a good inhibition effect on phoma citricarpa and colletorichum glecosporioides. The raw materials are rich; the operation is simple; the reaction is simple; the reaction conditions are mild; the purification post treatment is simple. Compared with a traditional antibacterial agent, the antibacterial compound has the advantages of simple structure, safety, no toxicity, little environment pollution and the like, and has good application prospects.
公开/授权文献:
- CN106631818B 二烷基氢化诺卜基苄基季铵盐的合成方法及其抗菌应用 公开/授权日:2018-03-20
IPC结构图谱:
C | 化学;冶金 |
--C07 | 有机化学 |
----C07C | 无环或碳环化合物 |
------C07C209/00 | 含氨基连接在碳架上的化合物的制备 |
--------C07C209/04 | .用氨基取代官能团 |
----------C07C209/06 | ..取代卤原子 |
------------C07C209/12 | ...生成季铵化合物 |