A building block combination structure comprises a bearing plate, a sitting plate, a building block assembling assembly, a limiting plate and a crawling assembly. An inner plate of a curtain wall is attached to the bearing plate. The sitting plate is attached to the bearing plate. The building block assembling assembly is arranged on the side face, far away from the bearing plate, of the sitting plate. The limiting plate is arranged on the side edge of the sitting plate. The limiting plate faces the building block assembling assembly. The crawling assembly comprises a crawling slope piece and an anti-skid protruding strip. The ends of the crawling slope piece are connected with the bearing plate and the sitting plate respectively. The crawling slope piece is provided with a crawling slope. The anti-skid protruding strip is arranged on the crawling slope. According to the building block combination structure, due to arrangement of the bearing plate, the sitting plate, the building block assembling assembly and the limiting plate, when a child crawls, the limiting plate can abut against the body of a child, the child is prevented from further crawling out of the sitting plate, and the better limiting effect is achieved. The building block combination structure further comprises a crawling assembly, so that due to arrangement of the crawling assembly, the child can better climb up the sitting plate.