The invention discloses a transportation device propelled by gas pressure differences and relates to the technical field of communication and transportation. The transportation device propelled by the gas pressure differences is characterized in that a high-pressure gas injection device and a compressed gas extraction device are embedded into the inner wall of a tunnel, the high-pressure gas injection device is connected with a compressed gas input pipeline, the compressed gas extraction device is connected with a compressed gas output pipeline, and the compressed gas input pipeline and the compressed gas output pipeline are embedded into the inner wall of the tunnel; seal door lifting devices are embedded into the inner wall of the tunnel and are connected with seal doors which are arranged in the tunnel, and airtight vehicles are arranged in the tunnel; the seal doors divide the tunnel into a plurality of reduced-pressure closed areas, and the airtight vehicles and the seal doors in front of and behind the same divide the reduced-pressure closed areas into low-pressure gas closed areas and high-pressure gas closed areas. The transportation device propelled by the gas pressure differences has the advantages that a power source is a reusable clean energy and is extremely environment friendly, so that consumption of existing energy sources is reduced, traveling comfort can be improved, and high practicality is achieved.