基本信息:
- 专利标题： 一种紫杉烷类抗肿瘤药物的聚合物胶束冻干制剂及其制备方法和应用
- 专利标题（英）：Polymeric micelle freeze-dried preparation of taxane anti-tumor drugs as well as preparation method and application of polymeric micelle freeze-dried preparation
- 申请号：CN201610802372.5 申请日：2016-09-02
- 公开(公告)号：CN106389355A 公开(公告)日：2017-02-15
- 发明人： 张兰 , 陈小新 , 龙超峰 , 谢称石 , 廖小英 , 白少伟 , 孙金鑫 , 钱志勇
- 申请人： 广东众生药业股份有限公司
- 申请人地址： 广东省东莞市石龙镇西湖工业区信息产业园
- 专利权人： 广东众生药业股份有限公司
- 当前专利权人： 广东众生药业股份有限公司
- 当前专利权人地址： 广东省东莞市石龙镇西湖工业区信息产业园
- 代理机构： 北京市广友专利事务所有限责任公司
- 代理人： 滕胜利
- 主分类号： A61K9/19
- IPC分类号： A61K9/19 ; A61K9/107 ; A61K31/337 ; A61K47/34 ; A61P35/00
The invention discloses a polymeric micelle freeze-dried preparation of taxane anti-tumor drugs as well as a preparation method and an application of the polymeric micelle freeze-dried preparation. The polymeric micelle freeze-dried preparation consists of a polyether/polyester segmented copolymer and taxane drugs, wherein the weight ratio of the polyether/polyester segmented copolymer to the taxane drugs is at (1-99) to 1; and in the polyether/polyester segmented copolymer, the molecular weight ratio of polyether to polyester is at 1 to (0.5-2). According to the taxane anti-tumor drug polymeric micelle freeze-dried preparation prepared by the invention, the physical stability of a redissolved solution is significantly increased; and meanwhile, the occurrence rate of a guinea pig allergic reaction in the taxane anti-tumor drug polymeric micelle freeze-dried preparation prepared from the polyether/polyester segmented copolymer which is subjected to ultrafiltration and freeze-drying treatment is obviously reduced, so that the safety of the taxane anti-tumor drug polymeric micelle freeze-dried preparation is further enhanced.
公开/授权文献:
- CN106389355B 一种紫杉烷类抗肿瘤药物的聚合物胶束冻干制剂及其制备方法和应用 公开/授权日：2020-01-17
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K9/00 | 以特殊物理形状为特征的医药配制品 |
| --------A61K9/10 | .分散液；乳剂 |
| ----------A61K9/19 | ..冻干的 |