The invention discloses a dynamic comprehensive weighing and toll collection system for truck ETC (Electronic toll collection) and belongs to the technical field of the truck ETC. The dynamic comprehensive weighing and charging system comprises a dynamic weighing data prejudging system, a prejudging control selection system, a truck weighing prejudging payment system, an ETC protocol toll collection system and a MTC (Manual toll collection) toll collection system; the dynamic weighing data prejudging system is used for detecting and weighing the truck and displaying weighing results and settlement methods and connected with the ETC protocol toll collection system; the prejudging control selection system provides reserve time and reserve regions to the truck to prompt carriageways and is connected with the ETC protocol toll collection system; the truck weighing prejudging payment system receives and select prompt messages; the ETC protocol toll collection system is used for monitoring the truck, reconfirming weighing and settlement and controlling electronic handrails; the MTC toll collection system is used for conducting weighing and toll collection of the truck selecting MTC. In the weighing and toll collection system, non-stop electronic toll collection of the truck can be effectively achieved, the truck is allowed to pass at high speed, traffic capacity and benefit are improved and management cost is reduced, and thus the weighing and toll collection system is also applicable to heavy traffic bridges and tunnels.