The invention provides a clean room with an automatic air-conditioner control system. The clean room comprises a clean room wall, a clean room ceiling, an upper air outlet, an upper air return inlet, a lower air outlet, a lower air return inlet, a return air integration part, an air integration part, a blower and a filtering device. The filtering device comprises a drying device, a dust removing device and a sterilization device, the filtering device is arranged between the blower and the air integration part, the air integration part is provided with two air supply ducts, and the two air supply ducts are respectively communicated with the upper air outlet and the lower air outlet, respectively, and the upper air return inlet and the lower air return inlet are communicated with the return air integration part respectively. The return air integration part is communicated with the air integration part, and the filtering device can also be added between the air integration part and the return air integration part. The clean room can shorten the recovery time of indoor temperature and humidity and the air flow speed, the effective use of the clean room is improved, and the energy consumed by the air conditioning system is reduced.