基本信息:
- 专利标题： 一种肽缩合试剂3’,5’-双三氟甲基联苯-3,5-二乙酸亚碘酰苯及其制备方法
- 专利标题（英）：Peptide coupling reagent 3',5'-bis(trifluoromethylbiphenyl)-3,5-iodobenzene diacetate and preparation method thereof
- 申请号：CN201510235954.5 申请日：2015-05-11
- 公开(公告)号：CN106278898A 公开(公告)日：2017-01-04
- 发明人： 张弛 , 刘姗姗 , 孙博
- 申请人： 南开大学
- 申请人地址： 天津市南开区卫津路94号
- 专利权人： 南开大学
- 当前专利权人： 南开大学
- 当前专利权人地址： 天津市南开区卫津路94号
- 代理机构： 天津佳盟知识产权代理有限公司
- 代理人： 侯力
- 主分类号： C07C71/00
- IPC分类号： C07C71/00
The invention provides a peptide coupling reagent 3',5'-bis(trifluoromethylbiphenyl)-3,5-iodobenzene diacetate and a preparation method thereof. The preparation method comprises the following steps: 1) synthesizing 3,5-dimethyl-3',5'-bis(trifluoromethyl)-4-aminobiphenyl; 2) synthesizing 3,5-dimethyl-3',5'-bis(trifluoromethyl)-4-iodobiphenyl; 3) synthesizing 3',5'-bis(trifluoromethyl)-4-iodobiphenyl-3,5-dicarboxylic acid; and 4) synthesizing 3',5'-bis(trifluoromethylbiphenyl)-3,5-iodobenzene diacetate. The invention has the advantages that the preparation method uses easily available raw materials, is simple in operation and is high in yield in each step; the synthesized coupling reagent has high reaction activity and enables peptide formation reaction of standard amino acid with sterically hindered amino acids to be finished within 30 min; and the peptide coupling reagent can be recovered and regenerated after simple post-treatment and makes mass usage of the reagent possible.
公开/授权文献:
- CN106278898B 一种肽缩合试剂3’,5’-双三氟甲基联苯-3,5-二乙酸亚碘酰苯及其制备方法 公开/授权日：2018-10-30