基本信息:
- 专利标题： 一种芳基酰胺类化合物的制备方法及其净化提纯方法
- 专利标题（英）：Preparation method of aryl amide compound and purification method thereof
- 申请号：CN201610580578.8 申请日：2016-07-22
- 公开(公告)号：CN106278775A 公开(公告)日：2017-01-04
- 发明人： 邓辰亮 , 张兴国 , 张小红 , 高旭红 , 徐薇
- 申请人： 温州大学
- 申请人地址： 浙江省温州市瓯海区东方南路38号温州市国家大学科技园孵化器
- 专利权人： 温州大学
- 当前专利权人： 温州大学
- 当前专利权人地址： 浙江省温州市瓯海区东方南路38号温州市国家大学科技园孵化器
- 代理机构： 温州瓯越专利代理有限公司
- 代理人： 曾建芳
- 主分类号： C07B43/06
- IPC分类号： C07B43/06 ; C07C231/10 ; C07C233/65 ; C07C235/46 ; C07C253/30 ; C07C255/57
The invention discloses a preparation method for synthesis of an aryl amide compound and a purification method. The preparation method comprises the following steps: various aryl iodides and alkyl primary amine, alkyl secondary amine or alkyl tertiary amine which are used as a substrate are heated in cyanobenzene used as a solvent under the catalysis of transition metal palladium salt and copper salt in carbon monoxide gas at atmospheric pressure to prepare a crude product; then, the crude product is filtered and the solvent is removed so as to obtain residue; the residue undergoes silica-gel column chromatography, elution is carried out by the use of an eluant, and an effluent is collected; the effluent containing the product is merged, the merged effluent is concentrated to remove a solvent; and finally, vacuum drying is performed to obtain a target product. The invention has advantages of simple process flow, low cost and high yield.
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07B | 有机化学的一般方法；所用的装置 |
| ------C07B43/00 | 含氮官能团的形成或引入 |
| --------C07B43/06 | .酰胺基 |