The invention discloses a method used for self-adaptive multiple control sources of a centralized intelligent gateway. The method comprises the steps of: configuring a communication channel in the centralized intelligent gateway, and activating or closing a corresponding communication port; establishing and maintaining communication among the centralized intelligent gateway, a plant station monitoring system and a remote communication host; completing the control process between the remote communication host and the plant station monitoring system according to a control operation uniqueness rule and a control authority checking rule by the centralized intelligent gateway, and recording a control command sent by the remote communication host; and carrying out time mark synchronization on the centralized intelligent gateway, the plant station monitoring system and the remote communication host regularly. The method realizes the effect that the centralized intelligent gateway extends the single communication channel of each plant station in a plurality of plant station systems to the communication channel suitable for a plurality of control centers under the preconditions of ensuring safe and stable operation of a power system by multi-host control and conforming to safety regulations, is high in adaptability, and is high in real-time performance.