The invention discloses a medicine box capable of preventing liquid medicine from sloshing and a production process of the medicine box. The production process of the medicine box comprises the following steps that 1, a medicine box upper mold and a medicine box lower mold which are matched with each other are manufactured; 2, partition plates are manufactured; 3, the medicine box lower mold is fixed to a rotating rod of a rotational molding machine, the partition plates manufactured in the step 2 are fixed in the medicine box lower mold, plastic powder is put into the medicine box lower mold, then the medicine box upper mold is locked on the medicine box lower mold, at the moment, the partition plates are located between the medicine box lower mold and the medicine box upper mold, and gaps are formed between the partition plates and the bottom wall of the medicine box lower mold as well as between the partition plates and the bottom wall of the medicine box upper mold; and 4, the rotational molding machine is started and transmits the rotating rod, the medicine box upper mold and the medicine box lower mold are made to rotate by 360 degrees in a machine furnace, the plastic powder is melted and uniformly paved on the medicine box molds, then cooling is conducted, the medicine box upper mold is opened, and thus the integrally-formed medicine box can be obtained.