基本信息:
- 专利标题： 一种常压下钯催化合成芳醛的方法
- 专利标题（英）：Method for synthesizing aromatic aldehyde under normal pressure through palladium catalysis
- 申请号：CN201610446905.0 申请日：2016-06-21
- 公开(公告)号：CN106008346A 公开(公告)日：2016-10-12
- 发明人： 韩维 , 周青
- 申请人： 南京师范大学
- 申请人地址： 江苏省南京市栖霞区文苑路1号
- 专利权人： 南京师范大学
- 当前专利权人： 南京师范大学
- 当前专利权人地址： 江苏省南京市栖霞区文苑路1号
- 代理机构： 南京知识律师事务所
- 代理人： 蒋海军
- 主分类号： C07D231/12
- IPC分类号： C07D231/12 ; C07D213/51 ; C07D333/22 ; C07D307/80 ; C07D277/24 ; C07D261/08 ; C07D263/32 ; C07D233/64 ; C07D207/333 ; C07D209/12 ; C07D209/86 ; C07C45/49 ; C07C47/54 ; C07C47/542 ; C07C47/546 ; C07C47/55 ; C07C47/544 ; C07C47/565 ; C07C47/575 ; C07C253/30 ; C07C255/17 ; C07C201/12 ; C07C205/44 ; C07C67/313 ; C07C69/76 ; C07C51/373 ; C07C65/30 ; B01J23/44
The invention discloses a method for synthesizing aromatic aldehyde under normal pressure through palladium catalysis, and belongs to the technical field of catalytic synthesis. According to the method, a palladium-catalyzed aryl halide and normal-pressure carbon monoxide is directly subjected to reduction coupling to prepare aromatic aldehyde in a polyethylene glycol solvent or a water solution of polyethylene glycol under the action of alkali and a reducing agent without needing participation of a ligand. The method for preparing aromatic aldehyde through a catalytic reduction coupling reaction has the advantages that the ligand is not needed, and the activity is good; the reaction is conducted at room temperature under the normal pressure, and the selectivity is high; a substrate is wide in source and stable; the compatibility of substrate functional groups is good, and the application range of the substrate is wide; a reaction medium is green and can be recycled. Under the optimized reaction conditions, the target product separation yield reaches up to 92%.
公开/授权文献:
- CN106008346B 一种常压下钯催化合成芳醛的方法 公开/授权日：2019-08-13
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D231/00 | 杂环化合物，含1,2-二唑或氢化1,2-二唑环 |
| --------C07D231/02 | .不与其他环稠合 |
| ----------C07D231/06 | ..环原子间或环原子与非环原子间有1个双键 |
| ------------C07D231/12 | ...只有氢原子、烃基或取代的烃基，直接连在环碳原子上 |