The invention discloses eyedrops applied to mid-aged people and aged people and a preparation method. The eyedrops are prepared from the following raw materials in parts by weight: 20-50 parts of concha haliotidis, 2-8 parts of cornu saigae tataricae, 5-10 parts of Chinese rhubarb, 10-20 parts of unprocessed rehmannia roots, 6-15 parts of dried orange peel, 15-25 parts of radix bupleuri, 12-20 parts of processed licorice roots, 6-15 parts of platycodon roots, 2-5 parts of travoprost eye drops, 6-15 parts of erigeron breviscapus, 1-5 parts of musk and 1-2 parts of borneol. The eyedrops suitable for being used for the glaucoma of mid-aged people and aged people are prepared through scientific compatibility, and are used for treating a common frequent eye disease namely senile glaucoma which is caused by that intraocular pressure rises relatively (low intraocular pressure glaucoma) or absolutely (high intraocular pressure glaucoma) due to discording viscera, dislocation of fluid and long accumulation of pathological products in eyes, and which has main clinical situations that people suffer from diseases of swelling pain of eyes, being dim-sighted during looking at things, diminution of vision, even dizziness, headaches, nausea, vomit and the like.