The invention discloses an insulating protection clamp for a secondary cable core. The insulating protection clamp comprises a base, an insulating housing and a spring clamp, wherein the insulating housing is fixed on the base; a wire core inserting hole is formed in the side surface of the insulating housing; the spring clamp is arranged in the wire core inserting hole and comprises a spring, an upper clamping piece and a lower clamping piece; a spring is arranged at the middle parts of the upper clamping piece and the lower clamping piece and is connected with the upper clamping piece and the lower clamping piece; the clamping piece at the lower part is fixed on the bottom surface of the wire core inserting hole; a groove is formed in the top part of the insulating housing; a through hole communicating with the wire core inserting hole is formed in the middle part of the bottom surface of the groove; a pressing device is arranged in the groove and the through hole; the bottom part of the pressing device and the tail end of the clamping piece at the upper part of the spring clamp are in contact; and opening and closing of the spring clamp are achieved through the pressing device. By the insulating protection clamp, the cable core can be quickly and conveniently isolated; the operation is convenient; the insulativity is good; the safety is high; and the arrangement and recovery efficiency of safety measures is improved.