基本信息:
- 专利标题： 纯化1,4,7,10-四氮杂环十二烷-1,4,7,10-四乙酸的方法
- 专利标题（英）：Process for purifying 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid
- 申请号：CN201580007531.6 申请日：2015-02-02
- 公开(公告)号：CN105939994A 公开(公告)日：2016-09-14
- 发明人： D.布夫菲 , X.博伊 , J.普伊佩
- 申请人： 爱克发医疗保健公司
- 申请人地址： 比利时莫策尔
- 专利权人： 爱克发医疗保健公司
- 当前专利权人： T2医药有限责任公司
- 当前专利权人地址： 比利时莫策尔
- 代理机构： 中国专利代理(香港)有限公司
- 代理人： 周李军; 林森
- 优先权： 14154106.0 2014.02.06 EP
- 国际申请： PCT/EP2015/052033 2015.02.02
- 国际公布： WO2015/117911 EN 2015.08.13
- 进入国家日期： 2016-08-05
- 主分类号： C07D257/02
- IPC分类号： C07D257/02
A process for purifying a compound of formula (1), comprising the following steps: a) adding an acid to an aqueous solution of the compound of formula 1, including salts thereof so as to obtain a pH<= 3 whereby a slurry is obtained; and b) filtering the slurry and at least one time washing the obtained precipitate with a liquid comprising water; and c) dissolving the precipitate obtained in step b) in water to obtain an aqueous solution; and d) filtering of the solution obtained in step c) over a nanofiltration membrane having a Molecular Weight Cut Off in the range from 150 to 500 and wherein optionally, between step c) and step d) the pH of the aqueous solution is adjusted to a pH value in the pH range as specified by the manufacturer of the nanofiltration membrane. A process for preparing a gadolinium complex of the purified compound of formula 1 is also disclosed. This gadolinium complex can be used for making a pharmaceutical composition as a contrast agent for magnetic resonance imaging.
公开/授权文献:
- CN105939994B 纯化1,4,7,10-四氮杂环十二烷-1,4,7,10-四乙酸的方法 公开/授权日：2018-05-29
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D257/00 | 杂环化合物，有4个氮原子作为仅有的杂环原子的环 |
| --------C07D257/02 | .不与其他环稠合 |