The invention belongs to the technical field of pharmacy and discloses a dobutamine hydrochloride decoloration technology. The technology comprises putting an anti-oxidant and dobutamine hydrochloride to be decolored into purified water, carrying out heating dissolution in an inert gas protective atmosphere, carrying out decoloration through adding active carbon into the solution, filtering to remove the active carbon in the hot solution, feeding the filtrate into a crystallization kettle, adding hydrochloric acid into the crystallization kettle, slowly cooling the filtrate so that solids are precipitated and carrying out filtration and drying to obtain white or off-white dobutamine hydrochloride. The technology can effectively remove colored substances in dobutamine hydrochloride, effectively inhibit impurity increasing caused by easy oxidation of dobutamine hydrochloride at a high temperature and produce a stable and high quality dobutamine hydrochloride finished product. The technology has the characteristics of simple processes, good decoloration effects, high yield, low cost and industrial production feasibility.