
基本信息:
- 专利标题: 一种吲哚衍生物的合成方法
- 专利标题(英):Method for synthesizing indole derivative
- 申请号:CN201610392535.7 申请日:2016-06-03
- 公开(公告)号:CN105884673A 公开(公告)日:2016-08-24
- 发明人: 陈久喜 , 于书玲 , 程天行 , 胡堃 , 戚林军 , 刘妙昌 , 吴华悦
- 申请人: 温州大学
- 申请人地址: 浙江省温州市瓯海区东方南路38号温州市国家大学科技园孵化器
- 专利权人: 温州大学
- 当前专利权人: 温州大学
- 当前专利权人地址: 浙江省温州市瓯海区东方南路38号温州市国家大学科技园孵化器
- 代理机构: 北京至诚君合知识产权代理有限公司
- 代理人: 董鹏; 唐维宁
- 主分类号: C07D209/08
- IPC分类号: C07D209/08 ; C07D209/10 ; C07D209/12
The invention relates to a method for synthesizing an indole derivative shown in the formula (III) (please see the specification). The method includes the steps that in a solvent and inertia gas atmosphere, when a catalyst, a nitrogen-containing ligand, an acid accelerator and KF exist, a compound in the formula (I) (please see the specification) and a compound in the formula (II) (please see the specification) are reacted, aftertreatment is carried out after the reaction is completed, and therefore the compound in the formula (III) is obtained, wherein R1 is selected from H or halogen, and R2 is selected from H, C1-C6 alkyl, C1-C6 alkoxy or halogen. According to the method, as a proper substrate, the proper catalyst, the proper nitrogen-containing ligand, the proper acid accelerator, the proper KF, the proper solvent and the like are comprehensively selected and cooperated, the range of the substrate is expanded accordingly, the indole derivative can be obtained with the good yield, the method has good application prospects and research value in the field of organic chemistry synthesis, and a brand new method is provided for synthesis of the compound.
公开/授权文献:
- CN105884673B 一种吲哚衍生物的合成方法 公开/授权日:2018-05-11
IPC结构图谱:
C | 化学;冶金 |
--C07 | 有机化学 |
----C07D | 杂环化合物 |
------C07D209/00 | 杂环化合物,含五元环、与其他环稠合、带1个氮原子作为惟一的杂环原子 |
--------C07D209/02 | .与一个碳环稠合 |
----------C07D209/04 | ..吲哚;氢化吲哚 |
------------C07D209/08 | ...只有氢原子或仅含氢和碳原子的基直接连在杂环的碳原子上 |