The invention provides a calculation method of tunnel lining design. The calculation method comprises the following steps: according to displacement continuous condition between a lining and a loosing circle and a water flow continuity condition among the lining, the loosing circle and an integral rock mass, calculating mutual acting force between lining concrete and the surrounding rock loosing circle during no crack; calculating the hoop stress of the inner surface of the lining concrete to calculate lining crack load and judge whether the lining concrete is cracked or not; calculating the mutual acting force between the lining and the surrounding rock loosing circle; judging whether the lining and the surrounding rock are separated or not, and determining an optimal reinforcement scheme of tunnel lining concrete. On the basis of a pervious lining theory and a lining surrounding rock conditional joint load mechanism, influence on a lining structure by the surrounding rock loosing circle is considered, a three-layer wall thickness cylinder model formed by the lining, the loosing circle and the integral rock mass is adopted to carry out tunnel lining design, a lining reinforcement scheme, and corresponding reinforcing steel bar stress on the crack, maximum crack width between the cracks and unit tube length seepage flow can be obtained.